This Saturday night, the stakes are high in the NFC as the Seattle Seahawks face off against the San Francisco 49ers. With both teams on winning streaks—Seattle rolling in with six consecutive victories and San Francisco matching this standing at six wins—they’re set for a thrilling matchup.
Seattle enters with a strong record of 13-3 after their recent 28-10 win against Carolina, while the 49ers hold a commendable 12-4 record following their narrow triumph over Chicago, 42-38. Seattle is leading the NFC West, but San Francisco is poised right behind them in the division rankings. Injuries could play a pivotal role in this game. Seattle will be missing starting offensive lineman Charles Cross due to a hamstring issue. Meanwhile, the Niners have several key players in question: Ricky Pearsall (knee, ankle), George Kittle (ankle), and Trent Williams (hamstring) are all uncertain for Saturday night’s contest.
The game starts at 8 p.m. ET at Levi’s Stadium in Santa Clara, California. Bookmakers have installed Seattle as a 2.5-point favorite, with the over/under set at 47.5 points according to DraftKings Sportsbook, which is down two points from the opening line. To gain insights and predictions, it’s wise to review the NFL projections from the SportsLine Projection Model, which simulates every NFL game 10,000 times for accurate analytics.
This model has performed impressively, showcasing a return of over $7,000 for $100 bettors on top-rated NFL picks since its inception and holds a record of 53-37 on these picks dating back to 2024. For the latest insights on the Seahawks vs. 49ers game, you can explore more via SportsLine.
The odds and trends for the game are as follows:
| Seahawks vs. 49ers spread | Seattle -2.5 at DraftKings Sportsbook |
| Seahawks vs. 49ers over/under | 47.5 points |
| Seahawks vs. 49ers money line | Seattle -144, San Francisco +121 |
| Seahawks vs. 49ers picks | See picks at SportsLine |
| Seahawks vs. 49ers streaming | Fubo (Try for free) |
Why the Seahawks can cover
Leading the charge for Seattle is veteran quarterback Sam Darnold. He has thrown for impressive stats this season, completing 67.2% of his passes for 3,850 yards, registering 25 touchdowns and 14 interceptions with a solid passer rating of 99.2. In crucial moments, like the recent overtime win against the Los Angeles Rams, he showcased his prowess by completing 22 passes out of 34 for 270 yards and two touchdowns. In another convincing win against Washington, he posted remarkable numbers by completing 21 out of 24 passes for 330 yards and four touchdowns.
His go-to target has been the talented wide receiver Jaxon Smith-Njigba. This third-year standout has racked up 113 receptions for 1,709 yards and 10 touchdowns over 16 games. His explosive play potential is evident with 27 plays of 20 yards or more and 505 yards gained after the catch, along with achieving 74 first-down conversions. In the last match against Carolina, he had a solid performance with nine receptions for 72 yards, marking his continued importance to the offense.
Why the 49ers can cover
For San Francisco, quarterback Brock Purdy has emerged as a reliable playmaker since his return from injury. He boasts a completion rate of 69.3%, accumulating 2,040 yards, 20 touchdowns, and nine interceptions with a notable passer rating of 104.2 in eight games this season. He is also an asset in the run game, contributing 126 rushing yards and three rushing touchdowns across 31 carries. In their recent battle against the Bears, he displayed his dual-threat capacity by completing 24 of 33 passes for 303 yards and three touchdowns, in addition to rushing for two touchdowns.
The key player for the 49ers is undoubtedly Christian McCaffrey, who remains vital to their success and faces no injury concerns despite some missed practice time this week. McCaffrey has carried the ball 303 times for an impressive 1,179 yards and 10 touchdowns this season. He also leads the receiving corps with 96 receptions, accumulating 890 yards and seven touchdown catches. In the game against Chicago, he delivered a remarkable performance, collecting 140 rushing yards and one touchdown, while also catching four passes for 41 yards.
How to make Seahawks vs. 49ers picks
According to SportsLine’s projections, the total points scored in this game should exceed 51. The model indicates that one side of the spread hits more than 50% of the time in simulations. To discover which team has the edge and to access expert predictions, check out SportsLine’s insights.
Who takes home the win in this crucial NFC matchup? With both teams showcasing their strengths, it’s time to weigh the options carefully. Find out which side of the spread consistently performs well and gain insights from the advanced model that has yielded substantial profits on NFL picks.
